Novel Characterization and Live Imaging of Schlemm's Canal Expressing Prox-1
Identifieur interne : 002768 ( Main/Exploration ); précédent : 002767; suivant : 002769Novel Characterization and Live Imaging of Schlemm's Canal Expressing Prox-1
Auteurs : Tan N. Truong [États-Unis] ; Hannah Li [États-Unis] ; Young-Kwon Hong [États-Unis] ; Lu Chen [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Schlemm's canal is an important structure of the conventional aqueous humor outflow pathway and is critically involved in regulating the intraocular pressure. In this study, we report a novel finding that prospero homeobox protein 1 (Prox-1), the master control gene for lymphatic development, is expressed in Schlemm's canal. Moreover, we provide a novel in vivo method of visualizing Schlemm's canal using a transgenic mouse model of Prox-1-green fluorescent protein (GFP). The anatomical location of Prox-1+ Schlemm's canal was further confirmed by in vivo gonioscopic examination and ex vivo immunohistochemical analysis. Additionally, we show that the Schlemm's canal is distinguishable from typical lymphatic vessels by lack of lymphatic vessel endothelial hyaluronan receptor (LYVE-1) expression and absence of apparent sprouting reaction when inflammatory lymphangiogenesis occurred in the cornea. Taken together, our findings offer new insights into Schlemm's canal and provide a new experimental model for live imaging of this critical structure to help further our understanding of the aqueous humor outflow. This may lead to new avenues toward the development of novel therapeutic intervention for relevant diseases, most notably glaucoma.
Url:
DOI: 10.1371/journal.pone.0098245
PubMed: 24827370
PubMed Central: 4020937
Affiliations:
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Truong</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Graduate Group in Vision Science, University of California, Berkeley, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate Group in Vision Science, University of California, Berkeley, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Li, Hannah" sort="Li, Hannah" uniqKey="Li H" first="Hannah" last="Li">Hannah Li</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Department of Surgery and Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery and Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Graduate Group in Vision Science, University of California, Berkeley, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Graduate Group in Vision Science, University of California, Berkeley, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>The Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco, San Francisco, California, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Schlemm's canal is an important structure of the conventional aqueous humor outflow pathway and is critically involved in regulating the intraocular pressure. In this study, we report a novel finding that prospero homeobox protein 1 (Prox-1), the master control gene for lymphatic development, is expressed in Schlemm's canal. Moreover, we provide a novel in vivo method of visualizing Schlemm's canal using a transgenic mouse model of Prox-1-green fluorescent protein (GFP). The anatomical location of Prox-1<sup>+</sup> Schlemm's canal was further confirmed by in vivo gonioscopic examination and ex vivo immunohistochemical analysis. Additionally, we show that the Schlemm's canal is distinguishable from typical lymphatic vessels by lack of lymphatic vessel endothelial hyaluronan receptor (LYVE-1) expression and absence of apparent sprouting reaction when inflammatory lymphangiogenesis occurred in the cornea. Taken together, our findings offer new insights into Schlemm's canal and provide a new experimental model for live imaging of this critical structure to help further our understanding of the aqueous humor outflow. This may lead to new avenues toward the development of novel therapeutic intervention for relevant diseases, most notably glaucoma.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maepea, O" uniqKey="Maepea O">O Maepea</name></author><author><name sortKey="Bill, A" uniqKey="Bill A">A Bill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cook, C" uniqKey="Cook C">C Cook</name></author><author><name sortKey="Foster, P" uniqKey="Foster P">P Foster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramos, Rf" uniqKey="Ramos R">RF Ramos</name></author><author><name sortKey="Hoying, Jb" uniqKey="Hoying J">JB Hoying</name></author><author><name sortKey="Witte, Mh" uniqKey="Witte M">MH Witte</name></author><author><name sortKey="Daniel Stamer, W" uniqKey="Daniel Stamer W">W Daniel Stamer</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Truong</name></region><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><name sortKey="Li, Hannah" sort="Li, Hannah" uniqKey="Li H" first="Hannah" last="Li">Hannah Li</name><name sortKey="Truong, Tan N" sort="Truong, Tan N" uniqKey="Truong T" first="Tan N." last="Truong">Tan N. Truong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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